What medications can be detected in workplace drug testing?

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While it’s perhaps not common knowledge, it is possible to fail workplace drug testing when using prescribed and over the counter medications.

Many people assume that workplace drug testing only detects illegal substances such as cannabis, heroin, methamphetamines, cocaine, and MDMA. However, this isn’t the case. Prescription medications and even some over-the-counter drugs can possibly be detected by workplace drug testing and, in certain circumstances, lead to complications at work.

In this blog we’ll look at why medications can potentially lead to a failed workplace drug testing result. We’ll also point out how you can avoid failing a test and stay safe while at work.

Why can you fail workplace drug testing after taking medications?

As highlighted on the Australian Government website Health Direct, some medications have side effects that can impact the ability for people to undertake some tasks safety. This can include driving and – particularly in safety-focused roles – working.

The website says: “Some medicines have side effects that can affect your driving. Like drink driving, it is illegal to drive under the influence of drugs, whether they are legal or illegal.”

The same applies to workplace safety. If a medication impairs your ability to perform your job safely, it can pose a risk to both you and those around you.

Common prescription medications that may be detected

Some medications, particularly those that affect the central nervous system, can impact on your ability to work safety. Some medications can also potentially be detected in workplace drug testing. A few examples may include:

  • Opioids – Codeine, morphine and fentanyl are all opioids, meaning they belong to the same drug family as heroin. These medications can cause drowsiness and impairment, making them a concern for workplace safety.
  • Benzodiazepines – Medications such as diazepam (Valium) and alprazolam (Xanax) are used for anxiety and sleep disorders but can affect concentration and coordination.
  • Antidepressants – Some types of antidepressants, particularly sedating ones, can cause drowsiness or dizziness, which may impact safety-sensitive tasks.
  • Antihistamines – While commonly used for allergies, some antihistamines can lead to drowsiness and slower reaction times.
  • Epilepsy Medications – Drugs used to manage epilepsy can also cause drowsiness or dizziness, which could impact workplace performance.

How to avoid failing a workplace drug test due to medication

If you are taking prescription medications and are concerned about workplace drug testing, there are steps you can take to ensure compliance and safety:

  • Avoid mixing medications with alcohol, as this can amplify their effects.
  • Always take medications as prescribed—never exceed or change the dosage without medical advice.
  • Consult your doctor to discuss how your medication may impact your ability to work or drive. Your doctor can provide guidance on managing side effects while remaining safe and compliant with workplace policies.
  • Do not “catch up” on missed doses by taking them too close together, as this can increase the risk of impairment.

Listen to your body

Another key way to avoid a failed workplace test due to medications is to monitor yourself for side effects. These can include drowsiness, dizziness, blurred vision, confusion, concentration issues and anxiety. If you experience any of these, stop working or driving and speak with your doctor.

Every person reacts differently to drugs – whether they be illegal or legal – so it’s important to be aware of how they affect you. If you feel unwell or impaired, avoid safety-sensitive tasks and seek medical advice. When in doubt, it’s always best to err on the side of caution—don’t drive or go to work if you’re unsure how a medication is affecting you.

By staying informed and proactive, you can continue taking the medications you need while ensuring workplace safety and compliance with drug and alcohol policies.

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While it’s perhaps not common knowledge, it is possible to fail workplace drug testing when using prescribed and over the counter medications.

By Michael

Michael is the founder of Integrity Sampling and is responsible for overseeing all national operations. He is based at Integrity Sampling's head office in Melbourne and is also responsible for the co-ordination of drug and alcohol testing within Victoria, assisting in the implementation of drug and alcohol (fit for work) policies and the presentation of drug and alcohol education and awareness programs. You can connect with Michael Wheeldon on LinkedIn

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